This talk introduces the consortium-wide effort doing within the EVEREST H2020 project. The EVEREST project aims at developing a holistic design environment that simplifies the programmability of High-Performance Big Data analytics for heterogeneous, distributed, scalable, and secure systems. Our effort is concentrated on the use of a “data-driven” design approach together with domain-specific language extensions, hardware-accelerated AI, and efficient run-time monitoring while considering a unified hardware/software paradigm. The project targets a wide range of applications from weather analysis-based production for the renewable energy market trading, to air-quality monitoring of industrial sites, and real-time traffic modeling for transportation in smart cities.